Using evidence to reduce the risk of Surgical Site Infection following primary total hip replacement in the UK

Lead Researcher: Dr Katharina Merollini

Collaborators: Professor Nick Graves

Healthcare acquired surgical site infection following total hip replacement decreases an individual’s quality of life, may cause their death and imposes substantial costs on the health care system. Current infection rates lead to high costs and poor patient outcomes. Preventing surgical site infection after hip replacements will improve health outcomes among hospitalized patients, save lives and release scarce resources for alternate uses, however preventing infection is a costly activity.

The goals of this research are to assess the cost-effectiveness of competing infection control strategies for hip replacements performed in NHS hospitals and make recommendations about which infection strategies to employ. An economic decision model is used to synthesise existing evidence on effectiveness of infection prevention strategies and related costs and health outcomes. Data sources include systematic reviews of the medical literature and information retrieved from five major NHS databases which were linked to enable accurate simulation of lifetime outcomes of this patient cohort.

The major benefit of this work will be the enhancement of infection control arrangements for total hip replacement which will improve National Health Services efficiency.

Graves N, Wloch C, Wilson J, Barnett A, Sutton A, Cooper N, et al. A cost-effectiveness modelling study of strategies to reduce risk of infection following primary hip replacement based on a systematic review. Health Technol Assess 2016;20(54)


Professor Nicholas Graves